针灸在实验性糖尿病和其他内分泌代谢相关性疾病中的作用研究进展

Advances of Research on Acu-moxibustion Treatment of Experimental Diabetes Mellitus and Other Endocrinous Metabolism-associated Dise ases

综述近年针灸在实验性糖尿病和其他内分泌代谢相关性疾病 (EMAD)中应用的研究进展。资料表明 ,针灸可用于治疗糖尿病和糖尿病慢性并发症 (血管、神经、视网膜病变等 ) ,以及改善Ⅱ型糖尿病及EMAD的胰岛素抵抗 (IR)作用 ;并对针刺的治疗作用进行了作用机制的探讨。

In the present paper, the authors review recent pr ogresses of acu-moxibustion tr eatment of experimental diabetes mellitus(DM)and insulin resistance(IR)of ty pe Ⅱ(TⅡ)DM and other endocrinous metabolism-associated diseases (EMAD )from 1) study on the effect of acu-moxibustion on experimental DM and its chronic comp li cations(diabetic vascular pathological change, nervous lesion and retinopathy) and mechanisms, and 2) study on the effect of acu-moxibustion on insulin growth fact or-1 receptor (IGF-1R) in TⅡDM and EMAD animals. In addition, the authors p ut f orward some existent problems in the research on DM, IR and EMAD, such as ① the generally acknowledged effective acupoints; acupuncture induced effect or stres s reaction, ② needling maneuvers, needle retention duration and stimulation int ensities, ③ systematic study on the effect of the metabolism of glucose and fa t, glycosylation-oxydation stress, aldose-reductase activity on the occurrenc e a nd development of the complications of DM, the interaction among hormones, and i ts relation to nerve-endocrine-immune network, ④ different levels of resea rche s including wholism, cytology and molecular biology, ⑤ the acting target site o f acupuncture, ⑥ indexes and evaluating methods for IR, ⑦ the effect of fre e fatty acid on IR, and ⑧ new trains of thought for improving IR.