化疗对胃癌Th1和Th2类细胞因子漂移的影响及临床意义

Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients

目的观察化疗对胃癌患者体内Th1和Th2类细胞因子表达的影响。方法采用逆转录聚合酶链反应(RTPCR)技术,检测胃癌患者在化疗前后外周血单个核细胞Th1和Th2类细胞因子的基因表达。结果胃癌患者外周血在化疗前呈Th2类细胞因子的强势表达;化疗后,Th2类细胞因子的表达减弱,甚至有向Th1类细胞因子漂移的趋势。结论化疗可降低Th2类细胞因子的表达,甚至有向Th1类细胞因子漂移的趋势,这可能与化疗抑制肿瘤的生长、有助于机体的预后和康复有关。

Objective To observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients. Methods Th1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR. Results The expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy. Conclusion The immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.