耐药基因及雌激素受体在大肠癌中检测及意义

Detection and Significance of Multidrug Resistance Gene and Estrogen Receptor in Colorectal Cardnoma

目的:探讨肿瘤耐药基因(P170)、谷胱甘肽S转移酶(GSTπ)及雌激素受体(ER)在人体大肠癌中表达及意义,为大肠癌的化疗及内分泌治疗提供依据。方法:采用免疫组织化学LSAB法,对108例大肠癌做了GSTπ检测,73例做了P170检测,40例做了ER检测。结果:多数大肠癌表达P170、GSTπ、ER,其中P170表达为61.61％(45／73),GSTπ表达率为69.44％(75／108),ER表达率为67.5％(27／40)。结论:多数大肠癌化疗药具有耐药性,提示临床在制定治疗方案中应针对性选择化疗药物,避免耐药性。同时对于ER表达阳性的大肠癌可考虑内分泌治疗。

Objective To study the expressions and significance of P170, GSTπ and ER in colorectal carcinoma in order to provide a basis for its chemotherapy and endocrinotherapy. Method The expressions of GSTπ in 108 cases of colorectal carcinomas, P170 in 73 and ER in 40 were determined by LSAB, immunohistochemical mithods. Result The positive rates of P170, GSTπ and ER expressions were 61.61%(45/73) ,69.44%(75/108) and 67.5%(27/40) respectively.Conclusion Most of the colorectal carcinomas are resistant to the drugs for chemotherapy. It is suggested that drugs for chemotherapy of the colorectal carcinomas should be chosen to avoid drug resistance. The colorectal carcinomas in which there is the positive expression of ER should be endocrinologi-cally treated.