摘要
目的 :建立 HPL C法测定复方吲哚美辛栓中硫酸沙丁胺醇的含量。方法 :采用 Dinamonsil C1 8柱 ,5 μm,4 .6 mm×2 0 0 mm;流动相 :磷酸二氢钠溶液 (用磷酸调 p H3.10± 0 .0 5 ) -甲醇 (85∶ 15 ) ,流速 1.0 ml·min- 1 ,检测波长 2 2 4 nm。结果 :硫酸沙丁胺醇在 9.6~ 38.4μg· ml- 1 范围内呈良好的线性关系 ,r=0 .99997,回收率为 99.95 %。结论 :该法快速、灵敏、准确。
Objective:To establish a HPLC method for determining salbutamol sulfate in Compound Indometacin Suppositories.Methods:The Dinamonsil C 18 column was used, mobile phase:Sodium dihydrogen phosphate (as phosphoric Acid to pH 3.10±0.5)-methanol(85∶15). The eluate with a flow rate of 1.0 ml·min -1 was detected at the wavelength of 224 nm.Results:The calibration curves were linear within the range of 9.6~38.4 μg·ml -1(r=0.999 97), the average recovery was 99.95%.Conclusion:This method is rapid, sensitive and accurate.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2005年第1期15-16,共2页
Lishizhen Medicine and Materia Medica Research