摘要
目的 :观察参麦注射液对大鼠脑出血后神经细胞凋亡相关基因的影响。方法 :采用Rosenberg法复制大鼠脑出血模型 ,测定脑出血后大鼠海马CA1区神经细胞病理形态结构及其Bcl 2基因、Bax基因表达 ;结果 :参麦注射液减少大鼠脑出血后海马CA1区锥体细胞凋亡数目 ,显著增加Bcl 2基因表达 ,降低Bax基因表达 ,使BaxmR NA/bcl 2mRNA比率下降。结论 :参麦注射液能调节凋亡基因 ,减少大鼠脑出血后神经细胞的凋亡。
Objective: To observe the effects of Shenmai(SM) injection on the neuronal apoptosis related gene expression in rat brain after intracerebral hemorrhage Method: With Rosenberg models of rat intracerebral hemorrhage, we studied the pathologic changes of neuronal structure in hippocampal CA 1 areas and gene expression of Bax and Bcl 2 Result: SM injection had effects on inhibiting the pyramidal cells apoptosis in the hippocampal CA 1 areas, increasing the expression of Bcl 2 gene, and reducing the expression of Bax gene resulting deceased the ratio of Bax mRNA /Bcl 2 mRNA Conclusion: SM injection can regulate the apoptosis gene, and inhibit the apoptosis in rat brain after intracerebral hemorrhage
出处
《中国中药杂志》
CAS
CSCD
北大核心
2004年第12期1160-1165,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金 (3 990 0 199)
湖南省自然科学基金 (99JJY2 0 0 3 )
中国博士后基金 (2 0 0 3 0 3 45 2 1)
