藏药然降多吉胶囊对大鼠佐剂性关节炎细胞因子及炎症介质的影响

Effects of Ranjiangduoji capsule on cytokines and inflammation mediators of adjuvant arthritis in rats

目的 :观察藏药然降多吉胶囊对大鼠佐剂性多发性关节炎的影响以及该药的免疫调节活性。方法 :用弗氏完全佐剂造成大鼠多发性关节炎 ,观察足跖肿胀程度、全身病变、脾脏T淋巴细胞增殖功能、腹腔巨噬细胞白介素 1(IL 1)分泌活性、血清脂质过氧化和超氧化物歧化酶 (SOD 1)活性。结果 :藏药然降多吉胶囊灌胃给药对弗氏完全佐剂所致大鼠继发的关节肿胀有显著的抑制作用 ,降低多发性佐剂性关节炎大鼠脾T淋巴细胞增殖转化率 ,抑制血清脂质过氧化产物的形成 ,对腹腔巨噬细胞产生白细胞介素 1(IL 1)分泌活性亦有一定抑制作用。结论 :然降多吉胶囊对佐剂性关节炎有显著的治疗作用 ,其机理与抑制T细胞增殖以及白细胞介素 1、过氧化脂质产生有关。

Objective: To study the effects of Ranjiangduoji capsule a traditional Tibetan medicine on cytokines and inflammation mediators of adjuvant arthritis(AA). Method: Polyarthritis model was induced by Freund's complete adjuvant in rats. The edema degree of the inflamed paws general affection T lymphocyte proliferation function, IL 1 activity secreted by celiac macrophage, peroxide lipid and SOD 1 in serum were detected. Result: Ranjiangduoji capsule, given orally, could inhibit the edema degree of the secondary inflamed paws, reduce T lymphocyte transformation, IL 1 activity of celiac macrophage, peroxide lipid in serum. Conclution: The anti AA action of Ranjiangduoji capsule is due to its inbition of T lymphocyte proliferation, IL 1 activity of celiac macrophage, and peroxide lipid.