四君子汤与环磷酰胺合用对荷瘤小鼠免疫功能的影响及抑瘤作用

Effect of Si Jun Zi Tang and Cyclophosphamide onimmmune and antitumor function in mice

用红细胞Ｃ３ｂ花环和免疫复合物花环形成试验观察了四君子汤与环磷酰胺合用对Ｓ１８０荷瘤小鼠红细胞免疫功能的影响及抑瘤作用。结果显示：四君子汤能增强小鼠红细胞Ｃ３ｂ花环形成率和血清中红细胞免疫粘附促进因子水平，降低免疫复合物花环形成率以及免疫粘附抑制因子的水平，并能桔抗环磷酸胺的免疫抑制作用，增强环磷酰胺的抑瘤效应。

he influence of Si Jun Zi Tang (SJZT) and Cyclophsphsmide (Cy) on red blood cell immune and antitumorfunction in S180 tumor transplanted mice was studied. The results showed that SJZT could increase C3b receptor rosetterate (C3bRR) and C3b rosette forming enhancement rate (RFER), but decrease immunocomplex rosette rate (ICR) androsette forming inhibition rate (RFIR) compared with tumor transplanted control mice (P<0. 05). SJZT could antag-onize immunosuppression of Cy compered with Cy control mice. SJZT combined with Cy would enhance antitumor ef-fect. It was suggeSted that SJZT was beneficial to recovery of immune function of tumor transplsnted mice.