大承气汤对实验性肠梗阻大鼠治疗作用的形态学观察

The morphological observation of Da Cheng Qi Tang in the experimental intestinal obstruction in rats

实验性肠梗阻大鼠摄食量和体重明显降低。光镜检察发现小肠粘膜上皮细胞肿胀,细胞界限不清,纹状缘消失,少数病例见部分上皮细胞坏死,脱落;粘膜下层、肌层及浆膜层明显淤血,小静脉明显扩张,间质明显水肿,嗜中性白细胞明显增多。大承气汤能显著改善肠梗阻时小肠组织的损伤程度,降低嗜中性白细胞的数量,治疗后的大鼠肠组织坏死脱落不明显,血管反应明显减轻,炎细胞的数量明显减少。大承气汤治疗肠梗阻引起形态学改变的机理可能与其抗炎、扩张肠道血管、改善肠组织的血氧供应、提高机体防御功能有关。

The morphological changes of the experimental intestinal obstruction were studied in rats. The intake and body weight were significantly decreased when compared with the control group (P<0.05). The abnormal changes of morphology include: edema of the intestinal epithelium, unclearness or disappear of the straited border in the most of the preparations; the local necrosis or fall of the epithelium in some of the preparations; obvious congestions in the submucosa myometrium and serous layer; the dilatation of small vein; the evident increase of neutrophil. The damage extent of intestinal tissues was improved by the treatment of Da Cheng Qi Tang (DCQT) in the experimental intestinal obstruction. DCQT inhibited the increase of neutrophil (P<0.05), alleviated both the degree of necrosis and the vascular response of the intestinal tissues (P<0.05), decreased the inflammatory infiltration. The results suggested that the enhancement of the defence functions, which include the effects of the antiinflammation, dilating the intestinal vessels, improving the oxygen supply in the intestinal tissues, may be involved in the mechanism of DCQT in the treatment of the intestinal obstruction.