药物动力学定域模型的建立和应用

Establishment and application of pharmacokinetic local model

目的 建立药物动力学定域模型并初步应用。方法 在房室模型基础上推导药物动力学定域模型,并由此得到药物动力学方程和若干重要参数。结果 该模型能正确描述药物在各种脏器和组织中的动力学行为,从而变房室模型的含混解释为本模型的直观解释。根据所推导的公式编制了计算机程序,计算结果表明,该模型理想地解释了实验结果。

Aim To establish and apply a new model called pharmcokinetic local model. Methods The local model of pharmacokinetics was deduced on the basis of multicompartment model, and phar macokinetical equation and several important parameters were obtained. Results The model could properly describe pharmacokinetic action of Pharmaceuticals in organs or other tissues. Thereby, ambiguous explanation of multicempartment model about pharmaceutical in a specific tissue is replaced by the visual explanation of the new model . According to formulae of the model, we complited the computer program and made some calculations. The results show that the model can ideally explain experimental facts.