健康志愿者口服对乙酰氨基酚的时间药代动力学

Chronopharmakinetics of acetaminophen administered peros in healthy volunteers

目的 研究不同时辰服药对乙酸氨基酚药动学的影响.方法 不同时辰服药,测定其唾液浓度,计算药动学参数.结果 与20:00组相比,8:00时服药,药物吸收较快,达峰时间较短,但吸收程度较差,清除较快,在体内的平均驻留时间较短.结论 早、晚服用对乙酸氨基酚,其代谢存在时辰差异.

Aim Effect of different chronos on acetaminophen pharmacokinetics was studied. Methods Afteracetaminophen was given at 8: 00 and 20: 00 by mouth, the drug concentrations in salivas were moni-tored and pharmakinetics parameters were calculated. Results Compared with at 20. 00, ac-etaminophen given at 8: 00 had more rapid absorption, shorter time of arriving at peak, but had worseahsorption degree, greater clearance, and shorter mean residence time.