老年高血压病患者卡托普利与阿替洛尔干预前后脑血流量的变化特征及其意义

Changes in volume of cerebral blood flow in elderly patients with essential hypertension after treatment to captopril and atenolol

目的 对比研究卡托普利(CPT)与阿替洛尔(ATL)对老年高血压病患者脑血流量的影响.方法选择年龄均在60岁以上的轻中度高血压病患者62例,随机给予CPT75～150mg/d或ATL50～100mg/d,分别于服药前后4周应用三维经颅超声多普勒测定患者颅内血管射血速度.结果服药前患者颅内血管平均流速均异常增高,服药4周后均明显降低,其中CPT组患者降至正常水平,ATL组患者却降至显著低于正常水平.结论 CPT可明显改善高血压病老年患者的脑血流量,而ATL则可使其异常减少.

Aim To study the effects of captopril and atenolol on volume of cerebral blood flow in el-derly patients with essential hypertension. Methods The velocity of cerebral blood flow (CBF) was measured with transeranil doppler before and after 4- week treatment of captopril (CPT) 75- 150mg! day, or atenolol (ATL) (50- 100 mg/ day) in elderly patients with EH. Results The mean velocity of CBF was signficantly increased before treatment of CPT or ATL, and it was reduced after treatment to normal level (in the CPT group) the and to an excessive lower level ATL group Conclusion CPT leads to an improvement of CBF, while ATL to decrese in elderly patients with EH.