拉西地平对原发性高血压的疗效及血浆内皮素、血管紧张素Ⅱ的影响

Effect of Lacidipine for Patents with Essential Hypertension and its Effect on Plasma Endothelin and Angiotensin Ⅱ Level

目的 观察拉西地平对原发性高血压(EH)的疗效及其对血浆内皮素(ET)、血管紧张素Ⅱ(AGT-Ⅱ)的影响.结果拉西地平(n=40)每日1次4～8mg,治疗4周,降低血压的显效率67.5%,总有效率92.5%;其中Ⅰ期、Ⅱ期的总有效率(100%和96.5%)明显高于Ⅲ期(33.3%);平均收缩压(SBP)、舒张压(DBP)和平均动脉压(MAP)分别下降23.8、19.7和22.7mmHg;24h动态血压监测(n=20)证实拉西地平可降低白昼和夜间的平均SBP、DBP和MAP(均p<0.01);同时降低血浆ET、AGT-Ⅱ水平.结论 拉西地平降压稳定、持久,剂量小,每日服用1次,耐受性良好.

Aim The effect of lacidipine for patients with essential hypertension and its effect on plasma endothelin and angiotensin II level were observed. Metheds Forty patients with essential hyper-tension were treated with lacidipine 4- 8 mg l/d, for 4 weeks. Ambulatory blood pressure monitor-ing(ABPM) was carried out in 20 patients. Result The responsive rate was 67. 5%, the total ef-fective rate was 92.5%.SBP, DBP and MAP were decreased 28.40 , 19.7 and 22.7 mmHg, re-spectively. The total effective rate in patients with essential hypertension in stageⅠ,Ⅱ was higher than that in patients in stageⅢ . We also found the plasma endothelin and angiotensin II level were decreased after lacidipine treatment. Conclusion The results suggest that lacidipine is a drug of stabilization, persistance, low dose (lid) and good toleration for the treatment of essential hypertension.