软珊瑚二萜葡糖苷的降压作用研究

STUDIES ON THE HYPOTENSIVE ACTION OF SOFT CORAL DITERPENE GLUCOSIDE(SCDG)

静脉注射软珊瑚二萜葡糖苷(soft coral diterpene glucoside,SCDG),能明显降低麻醉大鼠颈动脉压,量效关系明显,未见快速耐受现象;侧脑室给药,未见有降压效应;SCDG对肾上腺素的升压有增强效应;SCDG拮抗烟碱的升压作用;六甲双铵降压后SCDG不再降压。提示SCDG的降压机制可能和神经节阻断有关,而和中枢,外周M受体、α受体无关。

Soft coral diterpene glucoside(SCDG) ,a compound extracted from Cespit-ularia turgtda,obviously decreased the blood pressure of anesthetized rats. The dose range is from 0. 15 to 1. 2mg/kg iv, which presented a dose-effect relationship without rapid tolerance. The tachycardia induced by SCDG was not observed. Not being observed on anesthetized rats by injecting SCDG into Ventriculus lateralis cerebrialis ,the hypotensive action of SCDG on anesthetized rats didn't change by cutting nervus vagus while blocked by atropine; SCDG strengthened the hypertensive action caused by adrinaline (Adr);SCDG antagonized nicotine-induced hypertension, and didn't cause further lowering in blood pressure after blocking ganglia with hexamethylene-diamine (C6). The above experiments suggested that SCDG manifests neither the central hypotensive action nor direct action on peripheral M-re-ceptor or a-receptor,and the hypotensive mechanism of SCDG may be related to its ganglia-blocking effect.