胃癌c-erbB-2过度表达与预后的关系

Correlation Between Overexpression of c-erbB-2 Protein and Prognosis of Gastric Carcinoma

探讨c－erbB－2过度表达与胃癌预后的关系。方法：用免疫组化ABC法对103例胃癌手术标本及151个转移淋巴结进行c－erbB－2表达检测。结果：21．4％胃癌手术标本出现阳性表达．其中进展期胃癌、乳头状腺癌、高中分化胃癌及伴淋巴与肝转移的胃癌阳性率显著增高（P＜0．05与＜0．01）；转移淋巴结表达阳性率高于胃癌原发灶（X2＝3．7．P＞0．05）。高中分化胃癌伴c－erbB－2过度表达者5年生存率显著低于阴性者（P＜0．01）。结论：c－erbB－2过度表达可作为胃癌预后估计指标之一。

Objective: To investigate the correlation between overcxpression of c-erbB-2 protein and progonosis of gastric carcinoma. Method:Immunohistochemical reactivity to c-erbB-2 protein was examined in tumortissues and metastatic lymph nodes of 1 0 3 patients with gastric cancer. Results: Twenty two of 1 0 3 cases(21. 4 % ) were positive in expression of c-erbB-2. The incidence of c-erbB-2 positivity was significantly higher inadvanced cancers.papillary and well to moderately differentiated adenocarcinoma .and cancers with lymph nodeor liver metastasis (P<0. 05 and ＜0.01 ). The positive rate of c-erbB-2 in metastatic lymph nodes was higherthan in primary sites (X^2＝3. 7. p＞0. 05 ). Patients with c-erbB-2-positive tumors had poorer survival rates thanthose with cuerbB-2-negative ones in the well to moderately differentiated carcinonlas (P＜ 0. 01 ). Conclusion:Results indicate that examining c-erbB-2 overexpression may be helpful in predicting patients' prognosis for gastric cancer.