铝碳酸镁治疗胆汁返流性胃炎的实验与临床

The effect of Hydrotalcite on bile-reflux gastritis in Rats and Humanness

目的:观察铝碳酸镁对胆汁反流性胃炎的实验大鼠和临床胆汁反流性胃炎患者的治疗效果。方法:实验研究,纵形切开大鼠胃幽门括约肌,制造胆汁反流性胃炎的实验模型并喂饲不同剂量的铝碳酸镁或硫糖铝。二周或四周后取鼠全胃分送病理光镜与电镜检查。临床研究,胃镜下诊断为胆汁反流性胃炎的患者,随机接受铝碳酸镁或硫糖铝治疗并逐日记录临床症状,疗程结束时作胃镜复查。结果:临床观察见铝碳酸镁治疗胆汁反流性胃炎的一周显效率达42.36%,总有效率为89.66%;二周的治疗显效率达70.57%,总有效率为100%;铝碳酸镁的一周疗效与硫糖铝二周疗效相似,明显优于硫糖铝对照组(P<0.01)。实验大鼠的病理光镜与电子显微镜检查结果与临床所见相同。结论:铝碳酸镁是治疗胆汁反流性胃炎的有效药物。

Objective: to study the curative effect of hydrotalcite on bile-reflux gastritis. Methods: ① Bile reflux gastritis was produced in 30 rats with pyloric sphincter incision and the gastric mucosa of rats were examined with microscopy and electron microscopy after 2 and 4 weeks of treatment with hydrotalcite or sucrafate.② 250 patients with bile reflux gastritis between 1998. 11-2000. 10 were prospectively and randomly divided into two groups, the control group (n=47) treated with sucrafate and the lest patients (n=203) treated with hydrotalcite. The effect of treatments was evaluated by symptoms score. Result: ① The healing rate of gastric mucosa of rate with hydrotalcite (0.5/d) obviously more than with sucrafate (0. 5/d). ② The remarkable healing rate of symptoms score were separetly 42. 3%, 70.57% and the total effective rate were 89.66%, 100% after 1 and 2 weeks of treatment with hydrotalcite, that also obviously excels with sucrafate (P<0.01). Conclnslon: hydrotalcite is an effective drug on bile reflux gastritis.