疮疹病毒Ⅰ型胸苷激酶基因和更昔洛韦系统治疗脑恶性胶质瘤的临床观察及护理

Nursing of the Patients with Malignant Gliomas Treated with the PLTKcSN/VPC and GCV System

目的探讨和观察单纯疱疹病毒Ⅰ型胸苷激酶基因（TK）逆转录病毒载体生产细胞（PLTKcSN／VPC）结合羟甲基无环鸟苷（GCV）系统治疗（基因治疗）恶性胶质瘤的方法在人体内的安全性。方法在围手术期内对接受该治疗的患者进行临床观察和护理。结果19例患者接受该治疗后产生一些轻微的毒副作用，包括发热、神经系统症状、心血管及消化系统反应，对症处理后均可控制。结论通过密切观察和护理，可有效地预防和减轻治疗后不良反应。

Objective To evaluate the toxicity of the herpes simplex thymidine kinase gene(TK ) and ganciclovir(GCV) system in patients with malignant gliomas. Methods To retrospectively analyze the basic nursing materials of 19 patients obtained during peri-operative observation. Results Some slight side effects were found, including fever,symptoms of neruological system, and some changes in circulation and gastro-intestinal systems. All the side effects could be relieved after prompt treatment. Conclusion The toxicity effects of the PLTKcSN/VPC and GCV system could be effectively prevented and relieved through close observation and nursing.