对动脉粥样硬化斑块的新认识

New insights into atherosclerotic plaques

粥样硬化性动脉狭窄是脑梗死的主要病理生理基础。现代观点认为 ,脑梗死的发生与粥样斑块的活跃状态密切相关 ,而与斑块体积大小的关系不大。斑块的不稳定性或脆性决定于斑块内的脂质核心、巨噬细胞及斑块纤维帽。

The atherosclerotic arterial stenosis constitutes one of the major pathophysiologic bases of brain infarction.Recent observation suggests that the clinical events,such as stroke,depend more likely on the activity than on the volume of plaques.Risk factors which affect the instability of plaques are integrity of the fibrous cap,activity of macrophages and volume of the lipid pool.