青年临界无症状高血压病人的冠脉血流储备研究

THE CORONARY BLOOD FLOW RESERVE(CFR)IN YOUNG MEN WITH BORDELINE HYPERTENSION

目的:了解青年无症状临界高血压病人是否有冠状动脉功能异常。方法:经食道超声(TEE)研究组Ⅰ:20例正常人组,平均年龄39±3岁、血压115±13/70±5mmHg:组Ⅱ:17例无症状临界高血压患者,平均年龄36±4岁、血压136±23/83±10mmHg 的冠状动脉血流储备(CFR)。以潘生丁静注后和静息时舒张期的最大血流速度比率(D/R PDV)和收缩期最大血流速度比率(D/V PSV)作为 CFR 指标。结果:(1)两组受检者静息时的 PDV无显著差异(43±10 vs 46±8mm/s P>0.05)。(2)静注潘生丁后组Ⅱ的 D/R PDV、D/R PSV 较组Ⅰ明显减少,两组之间有显著差异(D/R PDV:2.25±0.36 VS 2.86±0.42、D/R PSV:2.0±0.26 VS 2.56±0.41,P<0.05)。结论:青年无症状临界高血压冠脉血流储备能力降低。

Ob jectives:To investigate whether functional abnormalities in coronary vasomotion arepresent in young men with bordeline hypertention.Methods:CFR of normal subjects(group Ⅰ:n=20,mean±SD,age 39±3 years,blood pressure 115±13/70±8 mmHg)and matched asymptomatic young men withbordeline hypertention(group Ⅱ:n=17 age 36±4 years,blood pressure 136±23/83±10mmHg P<0.001)werestudied with transesophageal Doppler echocardiography(TEE)technique.The radio of dipyridamole to restpeak diastolie velocity(D/R PDV)and dipyridamole to rest peak systolie velocity(D/R PSV)wereconsidered as indices of CFR.Results:(1)There were no difference of PDV between two group in rest(43±10 vs 46±8mm/s P>0.05)。(2)D/R PDV and D/R PSV were significanfly less in group Ⅱ verse group Ⅰ(D/RPDV:2.25±0.36 VS 2.86±0.42、D/R PSV:2.0±0.26 VS 2.56±0.41,P<0.05)。after dipyridamole infusion.Conclusions:There results demonstrate reduced coronary present in young asymptomatic men with bordelinehypertention.