摘要
目的探讨一氧化氮(NO),内皮素(ET-1)与开角型青光眼(POAG)的关系。方法测定POAG及对照组血清中的亚硝酸盐/硝酸盐(NO2-/NO3-),一氧化氮合酶(NOS)和血浆中的ET-1,并测量POAG患者的沿盘面积比,将其与相应的NO2-/NO3-,NOS,ET-1进行相关性分析。结果 (1)POAG中NO减少,ET-1升高。(2)在POAG早期视野损害阶段,NO减低,ET-1升高校中晚期视野损害阶段明显。(3)POAG的沿盘面积比与NO2-/NO3-呈负相关,与ET-1呈正相关。结论在POAG患者,可能有某些因素使NO减少,ET-1增加,造成了青光眼性视神经损害。
Objective To investigate the relationship of nitric oxide(NO),endothelin-1 (ET - 1 ) and primary open-angle glaucoma (POAG). Methods The concentration of NO2-/NO3-, NOS and ET - 1 in plasma (serum) of POAG and normal controls was detected by electrophotonomy and radioimmunoassay. The ralip of edge/optic nerve disc square (E/D ) of POAG patients were determined by Humphery retinal analyzer. Their level of NO2- /NO3-,NOS and AT - 1 were analysed, Results (l ) The level of NO in POAG patients was tow.T.but ET - 1 was higher. (2 ) The level of NO, ET - 1 In Initial stage was significantly different from the middle.late stage of vised field loss in P0AG patients. (3 ) The E/D of POAG patients. was negative correlation with their level of NO,and was positive correlation with their level of ET - 1. F.gpcluslon Some factors might decrease NO,but increase ET - 1 and reduce the blood supply of optic nerve,lead to the glaucomatous damage of optic nerve.
出处
《眼科研究》
CSCD
北大核心
2001年第3期269-270,共2页
Chinese Ophthalmic Research
关键词
青光眼
一氧化氮
内皮缩血管肽类
Glaucoma Nitric oxide Endothelium vasoconstrictor peptide