四联两周疗法治疗幽门螺杆菌感染

Tetradrug and two-week therapy for the treatment of Helicobacter pylon infection

目的：探讨幽门螺杆菌感染的药物治疗方法与意义。方法：１９８例消化性溃疡患者均经内镜检查、组织学检查和幽门螺杆菌快速检测确诊。随机分为 ３个治疗组即 ＡＭＣＯ组 ６８例、ＡＭＣ组 ６４例和 Ｏ组 ６６例，３组疗程均为 １４ ｄ。结果：消化性溃疡愈合率无显著差异。Ｏ组对幽门螺杆菌转阴率为１８．１％，明显低于其他两组（Ｐ＜０．０１）。结论：３组治疗方案均能使溃疡愈合，抗生素具有杀灭幽门螺杆菌疗效。

Objective: To study the pharmacotherapy of Helicobacter pylon (Hp) infection and significance. Methods: One hundred and ninety-eight patients with peptic ulcer (PU) were confirmed by fibroendospic and histological examinations and rapid test for Hp. They were randomly divided into three groups, namely, AMCO (n= 68), AMC (n = 64) and O (n = 66). The course of treatment was 14 days. Results: There was no significant difference for the healing rate of PU. The transforming rate of Hp from positive to negative in group O was 18. 1%, it was significantly lower than those in the other two groups (P<0. 01). Conclusion: All the treatment protocols for the three groups are effective in the treatment of peptic ulcer. Antibiotics are effective in killing Hp.