风湿热患者血清新蝶呤的改变

Changes of neopterin in patients with rheumatic fever.

目的 探讨风湿热患者血清新蝶呤的改变及其临床意义。方法 用ＥＬＩＳＡ 法检测急性风湿热风湿活跃期（ 活动期） 、慢性风湿性心脏病风湿静止期（ 静止期）及健康对照组血清新蝶呤的浓度。结果 ①活动期血清新蝶呤浓度（７．８４±６ ．３１ ｎｍｏｌ／Ｌ） 明显高于静止期（４．３１±２．５９ ｎｍｏｌ／Ｌ）（ Ｐ＜ ０ ．０５） 及健康对照组（２．９１±２．２６ ｎｍｏｌ／Ｌ）（ Ｐ＜０ ．０１） ；②静止期与健康对照组比较，血清新蝶呤浓度差异无显著性（ Ｐ＞ ０．０５） 。结论 风湿热患者血清新蝶呤在活动期增加，静止期下降，血清新蝶呤水平能反映疾病活动性，是风湿热细胞免疫激活的良好指标。

Objective To study the change and the clinical significance of neopterin in patients with rheumatic fever. Methods The concentrations of serum neopterin in patients with acute rheumatic fever(ARF), chronic inactive rheumatic heart disease(CRHD) and healthy controls were measured by ELISA method. Results The concentrations of serum neopterin in patients with ARF(7.84±6.31 nmol/L) were significantly higher than those in patients with CRHD (4.31±2.59 nmol/L, P<0.05) and healthy controls (2.91±2.26 nmol/L,P<0.01); the concentrations of serum neopterin in patients with CRHD were almost the same with those in the healthy controls (P>0.05). Conclusions The concentrations of serum neopterin increased in ARF, while decreased in CRHD. The serum neopterin levels can reflect the activity of the disease. Neopterin may be used as a marker to detect T cells activated by ARF.