肺炎患儿粒细胞-巨噬细胞集落刺激因子水平的初步探讨

Preliminary research on the levels of granulocyte-macrophage colony-stimulating factor in children with pneumonia

目的探讨粒细胞－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）在肺炎发生发展中的作用。方法采用放射免疫法检测３０例轻症肺炎、２０例重症肺炎伴心力衰竭患儿及２５例正常健康儿血浆中ＧＭ－ＣＳＦ水平。结果肺炎轻症组ＧＭ－ＣＳＦ浓度为１２７９±２０２ｐｇ／ｍｌ，肺炎重症组为９１４±２３９ｐｇ／ｍｌ，均较对照组（７５９±３１３ｐｇ／ｍｌ）明显增高，差异有显著意义（Ｐ＜００１，Ｐ＜０．０５）。结论ＧＭ－ＣＳＦ在肺炎的发生发展中可能起着一种免疫防御因子的作用。

Objective To explore the pathogenic effects of granulocyte-macrophage colony-stimulating factor(GM-CSF) in children with pneumonia.Methods The plasma levels of GM-CSF in children (30 cases of slight pneumonia, 20 cases of severe pneumonia complicated by heart failure, and 25 healthy children) were studied by radioimmunoassay.Results The plasma levels of GM-CSF in children with slight and severe pneumonia complicated by heart failure were 12 79±2 02 pg/ml and 9 14±2 39 pg/ml(P<0 01).The levels in the two groups were significantly higher than that in healthy children(7 59±3 13 pg/ml, P<0 01, P<0 05).Conclusions GM-CSF participates in the pathogenesis of penumonia in children.