南宁地区儿童肺炎衣原体感染的血清学调查

A serologic observation on chlamydia pneumoniae infection in children in Nanning area

目的 了解南宁地区呼吸道感染和无呼吸道感染儿童肺炎衣原体感染状况。方法 采用微量免疫荧光试验，对１４９ 例急性呼吸道感染患儿及１１１ 例对照组儿童（５５ 例同期住院的非呼吸道疾病患儿，５６ 例健康儿童） 进行血清肺炎衣原体特异性抗体ＩｇＧ，ＩｇＭ 检测。结果 ２６０ 例小儿肺炎衣原体抗体ＩｇＧ 阳性率２０ ％ ，其中１４９ 例急性呼吸道感染患者中ＩｇＧ阳性率２６ ％ ，对照组ＩｇＧ阳性率为１２％ ，两者差异有非常显著意义（Ｐ＜ ０．０１）。受试儿童＜ ３ 岁组肺炎衣原体抗体ＩｇＧ 阳性率为１６ ％ ，３ 岁～组为１５ ％ ，６ 岁～组为２４ ％ ，１２ 岁～１５ 岁组为４３％ ，阳性率随年龄增长而升高。１４９ 例急性呼吸道感染患儿中，２４ 例（１６％ ）为肺炎衣原体急性感染。结论 南宁地区各年龄组儿童都有一定比例的肺炎衣原体感染，临床上应重视小儿肺炎衣原体感染的问题。

Objective To understand the status of chlamydia pneumoniae (CP) infection in children with or without respiratary tract infection in Nanning area. Methods The specific serum IgG, IgM antibodies against CP were detected in 149 children with acute respiratory disease and in 111 control cases (55 with non-respiratory disorders and 56 healthy children). Results The positive IgG was 26% in children with acute respiratory disease and 12% in control children (P<0.01). The total positive rate of the specific serum IgG was 20%. The positive IgG rates in groups at age <3, 3～, 6～, and 12～15 years were 16%, 15%, 24%, and 43%, respectively. Twenty-four of the 149 patients (16%) had acute CP infection. Conclusions CP infection is widely present in all age groups of children in Nanning area and the infection rate increases with age.