大鼠肝癌模型的建立及影像学表现

Establishment of a Rat Model Carrying Hepatocellular Carcinoma and Analysis of Its Imaging Features

用二乙基亚硝胺诱发大鼠肝癌，观察其影像学表现，同时与病理学进行对照。结果，３０只雄性Ｗｉｓｔａｒ大鼠中，诱癌过程死亡１３只，余１７只经病理学检查，证实均成功诱发出肝癌灶。癌结节直径为０２～２．５ｃｍ，每个肝脏平均有９±２１个。其影像学特征为：平扫ＣＴ癌结节为略低密度区，增强扫描低密度影显示更加清楚；ＭＲＩＴ１加权像呈等或略低信号，Ｔ２加权像为高信号。认为化学诱导法建立的大鼠肝癌模型具有人肝癌相似的影像学表现，是一种适合于医学影像学研究的理想模型。

The aims of present study were to establish a rat model with hepatocellular carc inomas(HCCs) with chemical carcinogen, and to correlate its computer tomographic and magnetic resonance features with pathologic changes. 30 male wistar rats we re orally administered with diethynitrosamine (DENA) at a concentration of 100μ g/ml for consecutive three months. During tumor inductive period, 13 wistar rats died, while 17 survived rats were proven with HCCs pathologically. At autopsy, the HCC nodules varied 0.2～ 2.5cm in diameter. The nodular number of earch liver averaged 9±2.1. On plain CT images, most of the nodules were visualized as hyp odense, while on post contrast images, the nodules were clearly demonstrated as hypodense agaist surrounding liver parenchymas which had considerable contrast e nhancement. On T 1 weighted images, the nodules displayed iso-or slightly hypoi ntense, on the contrary, the nodules appeared as hyperintense on T 2 Weighted i mages. Therefore, the rat model with HCCs induced with DENA may not only mimic t he pathophysiological procession of humen hepatocarcinogenesis, but also has ima ging features like humen HCCs. It is an ideal model for medical imaging study.