摘要
本文观察了用抗氧化剂维生素E预处理后,三氯乙烯(3000mg/kg B-W-) 一次性经口染毒24h 大鼠肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及丙二醛含量的变化,结果表明三氯乙烯染毒组肝脏中丙二醛含量、超氧化物歧化酶活力及血清谷丙转氨酶、谷草转氨酶活力均高于对照组(P< 0-01) ;而维生素E干预组的丙二醛含量、超氧化物歧化酶活力及血清谷丙转氨酶、谷草转氨酶活力均分别低于三氯乙烯染毒组(P< 0-01) ,说明三氯乙烯急性染毒可引起肝脏脂质过氧化反应及肝损害,肝脏超氧化物歧化酶活力升高可能是机体受自由基及脂质过氧化反应刺激而诱导产生的一种适应性反应,维生素E对三氯乙烯所致的肝损害有一定的保护作用。
After single oral administration (by gavage) of trichloroethylene (3000mg/kg B.W.), the serum and liver were colletted. The activity of serum GPT and GOT (as indices of liver damage) were measured. Also, The activity of superoxide dismutase (SOD)、 glutathione peroxidase (GSH-Px) and the level of malondialdehyde (MDA) were analysed in the liver homogenate of the rats. The results revealed the activity of liver SOD and serum GPT、GOT in the rats acutely exposed to trichlorothylene (TCE) was significantly higher than those of the control (P<0.01). Pretreatment with vitamin E could reduce the level of liver MDA and the activity of liver SOD、 serum GPT and GOT. It is suggested that TCE might induce lipid peroxidation in the liver of rats and vitamine E could protect liver from TCE-induced liver damage in some degree.
出处
《中国实验动物学报》
CAS
CSCD
1999年第2期86-89,共4页
Acta Laboratorium Animalis Scientia Sinica
