天花粉蛋白治疗奶牛胎衣不下症奶中药物残留的检测

RESIDUE ANALYSIS OF TRICHOSANTHIN IN MILK

本研究用放免分析法检测了41头子宫灌注天花粉蛋白(TCS)治疗胎衣下不奶牛奶中的残留量。结果表明,个体差异较大,但总体平均仍表现一定的规律:奶中TCS浓度在投药后6小时内升为高值;在12～18小时下降至谷值,18～24小时上升至最高值(35.0±12.6ng/ml);在30～36小时锐减;此后平缓波动下降,至129小时左右为零。用TCS治疗奶牛胎衣不下症,牛奶的食用是安全的。

The study used RIA of Trichosanthin (TCS) to detect TCS contents in milk samples, which were collected from 41 milk cows retened fetal membrane (RFM) after administrating TCS concentrations as following: the value in 0—6 hr was high, and the contents fell to a valley floor from 6 to 18hr; the contents increased sparply to a peak value 35.0±12.6ng/ml in 18—24hr and then dropped in 30—36 hr, after 36—th hr the value decreased undulately untile undetected about 129—th hr. Basing on other factors, the authors think it is safe to drink the milk got from the cow which was treated for RFM by TCS. The results also indicate that TCS belongs to the fast-excretion type in the animal's body. So it's safe for cows, too. According to the clinical studies on human beings and this study, the authors put forward a hypothesis about the metabilic processsion of TCS and suggest that the uterus should be washed after the delivery of fetal membrane, so as to decrease the residue and duration time of TCS in milk.