糖化低密度脂蛋白与颈动脉粥样硬化的关系研究

The relationship between glycosylated low density lipoprotein and carotid atherosclerosis

目的 通过比较颈动脉粥样硬化患者与对照组之间的糖化低密度脂蛋白的血浆含量 ,寻找颈动脉粥样硬化与糖化低密度脂蛋白之间的关系。方法 颈动脉粥样硬化组 1 0 3例 (其中合并糖尿病组 47例 ,不合并糖尿病组 56例 ) ,对照组 43例。应用微柱亲和层析法分别测定两组糖化低密度脂蛋白的含量。结果 颈动脉粥样硬化组 (糖尿病组和非糖尿病组 )糖化低密度脂蛋白含量均较对照组明显增高 (P <0 .0 1 )。颈动脉粥样硬化造成动脉的狭窄程度与糖化低密度脂蛋白呈明显正相关 (r =0 .40 93 ,P <0 .0 1 )。非糖尿病合并颈动脉粥样硬化组的患者午餐后 2h血糖增高 ,同时胰岛素也明显增高 ,差异有显著性意义 (P <0 .0 5)。提示葡萄糖耐量异常和高胰岛素血症的存在。

Objective To find out the relationship between the g1ycosylated LDL and carotid atherosclerosis and the new routes in prevention and treatment of diabetic atherosclerosis.Methods There were 103 patients in carotid atherosclerosis group.Of them,47 suffered from NIDDM and 56 were non diabetics. The contro1 group consisted of 43 patients who had no diabetic history and no sign of atherosclerosis. Gly LDL was determined by aminobenylborate gel affinity chromatography.Results Gly LDL levels in both the carotid atherosclerosis group and non diabetic group were significantly higher than that in control( P <0.01). There was a significant correlation between the stenotic severity in carotid artery and Gly LDL level (r= 0.4093,P< 0.01 ). Among the non diabetics in carotid atherosclerosis group,the blood glucose level and insulin level were higher 2 hours after meal as compared with the NIDDM and control group with significant difference (P<0.05) .It means impaired glucose tolerance and hyperinsulinemia. Conclusion Gly LDL plays an important role in pathogenesis of carotid atherosclerosis in patients with NIDDM and non diabetics.