肠道小细胞癌的临床病理研究

Clinical-pathological behavia of small cell carcinoma of the intestines

报道9例肠道小细胞癌(ISCC)。通过病理组织形态、组化及免疫组化,并结合临床表现对此癌进行回顾性研究。结果表明:ISCC较少见,占肠道上皮性恶性肿瘤的1.2％;组织学形态可分为四型,即雀麦细胞型;淋巴细胞样型,中间细胞型以及复合性细胞型;免疫组化染色其神经内分泌标记阳性率较高,对NSE和CgA显示一定敏感性和特异性反应;ISCC有较明显侵犯血管倾向(87.5％),淋巴结(62.5％)和肝(66.7％)转移率较高,预后不良,这些临床与病理特征和肺小细胞癌相似。采用综合治疗可望提高此癌患者的生存期。

There are 9 cases of intestinal small cell carcinoma (ISCC) studied in this report. It is a retrospective study in pathohistomorphology,histochemistry and immunohistochemistry with refessence to the clinical significance. The results show as follows: ISCC is rare and constitutes 1 percent of malignant epithelial tumors in those locations. According to the histornor-phology,they are divided into four types: oat cell type,lymphoid cell type, intermediate cell type,and combined type. The positive rate of its neuroendocrine marker is high by immunohistochemical staining, while NSE and CGA are in a certain extent specific and sensitive to it. There is high tendency of metastasis to lymphnodes (62. 5%), to liver (66. 7%) and to blood uessels(87. 5 %). The prognosis is worse. These characteristics in clinic and pathology is similar to small cell carcinoma of lung. Complex treatment must be taken to prolong patient's survival time.