梧州市部分职工干部的鼻咽癌血清学筛查

Mass serological survey for nasopharyngeal carcinoma in the part of workers and officers in Wuzho city

目的:对梧州市部分职工、干部28745人进行鼻咽癌血清学筛查,发现早期鼻咽癌病人。方法:应用免疫酶法测定血清中EB病毒VCA-IgA抗体。结果:(1)EB病毒VCA-IgA抗体阳率4.00％,在阳性者中检出鼻咽癌病人36例,其中16例为放疗后病人。新确诊20例,早期19例;晚期1例,早诊率为95.00％。(2)阳性人群、新确诊和经放疗后病人的抗体GMT分别为11.37、52.78、23.79。(3)放疗后病人的抗体GMT 23.79较放疗前146.80低六倍,而生存期<5年、>5年、≥10年者,其GMT分别为45.95、19.95、13.19。结论:结果表明在人群中进行鼻咽癌血清学筛查可以检出鼻咽癌和早期病人,同时提出能否根据抗体滴度的变化,作为临床判断鼻咽癌病人预后预测病情的指标,有着重要的参考价值。

Purpose:We detected EB virus(EBV) VCA-IgA,to find nasopharyngeal carcinoma(NPC) in early stage,in 28745 workers and officers in Wuzhou city. Methods:The inmunoenzyme test was used to detected EB virus VCA-IgA. Results: VCA-IgA positive rate was 4. 00%. Found 36 cases NPC in group with VCA-IgA positive, in which there were 16 cases patients after radiotherapy and 20 cases new patients(19 cases in early stage and a case in late stage). NPC early stage diagnosis rate was 95. 00%. Geometric medial titer (GMT) in VCA-IgA positive group and new NPC patients and patients after radiotherapy were seperately 1: 11. 37 and 1: 52. 78 and 1 : 23. 79, GMT of 16 patients after radiotherapy (1 : 23. 79) was lower than before treatment (1 : 146. 8). When survival stage after radiotherapy sperately were 5 years and≥5 years and≥10 years GMT were 1 : 45. 95 and 1 : 19. 95 and 1: 13. 19. Conclusions:results showed that using VCA-IgA test can find out early stage NPC patients and the test is easy and adapts to mass survey. It indicates there is important reference value with VCA-IgA litre change to NPC prognosis.