胸水肿瘤标志物测定对癌性积液的诊断价值

The diagnostic value of detecting tumor marker for malignant effusion

分别测定43例胸腔积液患者的血清与胸水肿瘤标志物(CEA、NSE、CA_(212)、CYFRA_(21-1)含量,其中癌性积液28例,非癌性积液15例。发现胸水中肿瘤标志物含量均明显高于血清水平;CEA、NSE、CA_(212)三者联合应用在胸水中敏感性高达92.8％,特异性96.2％,而血清中相应为75％,87.5％;CYFRA_(21-1)在非癌性组中阳性率较高,但数值明显低于癌性积液组(P值<0.01)。提示测定胸水肿瘤标志物对恶性积液的诊断具有临床应用价值。

To detect the content of tumor marker in serum and pleural liquid of 43 cases pleural effusion,included malignant effusion 28 cases,nonmalignant effusion 15 cases. Discovered the content of tumor marker in the pleural liquid was obviously higher than in the serum. The, sensitivity and the specificity of combining apply of CEA,NSE,CA242 in the pleural liquid was highly 92.8% and 96.2% respectively in comparison with in the serum was 75%and 87. 5% respectively. The sensitivity of CYFRA21-1 was slightly high in the nonmalignant effusion,but the content in the nonmalignant effusion was low compare to the malignant effusion(P<0. 01),This indicate that detect the tumor marker of pleural liquid was significant on diagnosis of malignant effusion.