摘要
用MNNG复制Wistar大白鼠腺胃癌。选用31只难性大白鼠,体重为110～120g,给25只大白鼠白山饮服MNNG100 mg/L为实验组,6只大白鼠给饮自来水作为对照组。实验组分别于实验后24、44、64、68周处死或自然死亡;对照组于44、64、68周各处死2只。于68周时处死解剖之12只大鼠小,有6只产生腺胃高分化腺癌并伴癌前病变。ConA、PNA受体的标志,发现对照组及无癌形成实验组大鼠腺胃ConA受体呈膜性分布,PNA受体除壁细胞、主细胞外,均呈阴性,于癌灶及不典型增生区显示膜性分布及浆性分布,表示糖基有改变。
In order to observe the relationship between gastric carcinoma and precancerous lession of gastric mucosa, a reproducible model has been made in 31 wistar rats with MNNG. Adenocarcinoma. dysplasia, erosion, ulcer, and intra-mucosal cyst in adenostomach; verrucose hyperplasis, papilloma and squamous cells carcinoma in antestomach have been studied. The incidence of the adcnocarcinoma was 6/12. ConA, PNA markers showed the distributive polarity of the positive were disappeared in a denocarcinomed, also in dysplasia, and it displaicd the contrary in the perictal and chief cells of the eontrl group and non-cancr formed cases. It was different from human lectin labelling of gastric mucosa.
出处
《苏州医学院学报》
1993年第1期9-11,84-85,共3页
Acta Academiae Medicinae Suzhou
关键词
癌前病变
凝集素
胃肿瘤
褐家鼠
wistar rats
N-methy 1-N-nitro-N-nitrosoguanidine MNNG
adenogastric carcinoma
precancerous lession
lectin
