栓塞化疗43例中晚期肝癌预后因素分析

The analysis of progrostic factor in 43 advanced hepatocellular carcinoma patients with TACE

目的 综合分析影响接受栓塞化疗中晚期肝癌患者预后的主要因素。方法 采用Cox回归模型 ,对 4 3例中晚期肝癌栓塞化疗术后进行随访 ,对影响预后因素进行分析。结果 总体 0 5、 1、 1 5、 2年生存率分别为 76 74 %、 4 6 5 1%、 2 5 5 8%、 13 95 %。影响预后的主要因素为AFP变化情况、肿块大小、肿瘤供血情况。结论 肝动脉栓塞化疗术治疗前后AFP减少值与治疗前AFP比值大于 5 0 %的患者生存期明显延长 ,其能预测其疗效。肝动脉栓塞化疗术是治疗中晚期肝癌的主要手段。

Objective To evaluate the prognostic factors in unresectable HCC patients with TACE.Methods 43 patients with advanced HCC were treated by TACE.They were followed up for 2 years.Survival time began with the time of diagnosis.Parameters likely to affect prognosis were submitted to univariate and multivariate analysis using Cox propotional hazard regressia model.Result The overall 0.5-year,1-year,1.5-year and 2-year survival rates were 76.74%,46.51%,25.58% and 13.95% respectively.Multivariate analysis revealed the factors in the regression equation were the change of AFP value,tumor size,blood supply of tumor.Conclusion The patient's survival time prolonged obviously while his or her value of AFP after TACE decreased over 50% of that,therefore the chang value of AFP can be a index to predict the treatment effect.