雷米普利对2型糖尿病患者左心室舒张功能的影响

The Effect of Ramipril on the Left Ventricular Diastolic Function in Patients with Type 2 Diabetes Mellitus

目的 探讨雷米普利对 2型糖尿病患者左心室舒张功能的影响。方法 将 12 1例中年 2型糖尿病患者随机分为常规治疗组和雷米普利组 ,雷米普利组在常规治疗基础上加雷米普利治疗 6个月。用彩色多普勒超声诊断仪在治疗前、后测量各房室径线、二尖瓣血流E峰 (E)、A峰 (A)和等容舒张时间 (IVRT) ,并在Valsalva动作时重新测量E、A和IVRT。计算E/A比值和左心室重量指数 (LVMI)。结果 2型糖尿病患者左心室舒张功能不全率为 4 2 98% ;两组患者治疗前与治疗 6个月后收缩压、LVMI和E、A、IVRT、E/A均值间差别均有显著性意义 (P均 <0 0 5 )。结论 雷米普利可改善 2型糖尿病患者左心室舒张功能。

Objective The aim of this study was to investigate the effect of ramipril on left ventricular diastolic function in patients with type 2 diabetes mellitus.Methods 121 middle-aged patients with type 2 diabetes mellitus were randomly divided into conventional treatment group and ramipril group.The ramipril group was given ramipril in addition to conventional treatment.Echocardiographic examination was performed before and after 6 months treatment.Measurements included the dimensions of atria and ventricle,mitral E-wave velocity (E),A-wave velocity (A),and isovolumic relaxation time(IVRT).The E,A and IVRT were measured again during phase Ⅱ of the valsalva maneuver,E/A and left ventricular mass index were calculated.Results The prevalence of diastolic dysfunction was 42.98% in patients with type 2 diabetes mellitus.After 6 months′ treatment,the differences of the E,A,E/A,IVRT and LVMI between the two groups were significant(P<0.05).Conclusion Ramipril improves the left ventricular diastolic function in patients with type 2 diabetes mellitus. Diabetes Mellitus