急性缺血性脑血管病病人血小板颗粒膜蛋白的研究

The Study of Platelet Granule Membrane Protein in Patient with Acute Ischemic Cerebrovascular (ICVD) Disease

目的 探讨缺血性脑血管病血小板活化的规律及其与临床的关系。方法 用流式细胞术检测了 66例缺血性脑血管病病人全血血小板颗粒膜蛋白GMP -14 0 ,并按病情、病程进展和梗死面积分组 ,同时设对照组比较。结果 缺血性脑血管病无论TIA、脑梗死轻型或重型GMP -14 0均升高 ,重型组升高最显著 ;急性期较相对稳定期、恢复期升高显著 ;大面积梗死组较小面积梗死和多发性梗死GMP -14 0升高显著。结论 缺血性脑血管病病人血小板活化与病情、病程进展及梗死大小有关 ,GMP -14 0可作为判断病情的指标。

Objective To study the clinical significance of activated platelet in patients with acute ICVD.Methods We had examined GMP-140 in 66 patients with acute ICVD (including TIA, minor grade infarction and severe grade infarction) as well as 30 normal controls. Results GMP-140 was significantly higher in patients with ICVD than that in controls. It was much higher in severe grade group than those in minor grade group and TIA. It was higher in acute period than in other periods. It was significantly higher in patients with big area infarction than in patients with small area infarction and lacunar infarct. Conclusion There is relation between activated platelet and the degree of seriousness, developing, area of infarction in patient with ICVD. GMP-140 can be served as parameter to evaluated the state of ICVD.