山东省临沂地区710例EB病毒VCA—IgA抗体检测结果的分析

ANALYSIS OF RESULTS OF 710 CASES OF EPSTEIN—BARR VIRUS VCA—IGA ANTIBODY IN LINYI PREFECTURE

报告临沂地区710例EB病毒VCA—IgA抗体检测结果。放疗前鼻咽癌组(Ⅰ组)47例,抗体阳性率80.9％,几何平均滴度(GMT)为1:18.57,远远高于鼻咽癌放疗后组(Ⅱ组),头颈部其他肿瘤组(Ⅲ组)、鼻炎、鼻衄组(Ⅳ组)和正常人组(Ⅴ组)。经T检验,除Ⅰ组与Ⅱ组阳性率比较有显著差异(P<0.05)外,Ⅰ组与其他组阴性率与GMT比较均有非常显著性差异(P<0.01),Ⅰ组与Ⅱ组GMT比较也具有非常显著性差异(P<0.01)。结果表明,该抗体检测诊断鼻咽癌具有较高的特异性和灵敏度,可作为鼻咽癌诊断、鉴别诊断、疗效观察和判断预后的指标之一。

Results of 710 cases of Epstein—Barr virus(EB virus) VCA—IgA antibodies in Linyi Prefecture were analyzed. They are group Ⅰ: 47 patients with nasopharyngeal carcinoma before radiotherapy, group Ⅱ: 32 patients with nasopharygeal carcinoma after radiotherapy; group Ⅲ: 68 patients with other tumors of head and neck; group Ⅳ: 223 patients with rhinitis and epistaxis. The results showed that the positive rate of VCA—IgA antibody in Group I was 80.9%, geometric mean titer(GMT) was 1: 18.57, both were higher than those in other three groups(P<0.01), which means that the VCA—IgA antibody is highly specific and sensitive in detecting the nasopharyngeal, and may be a marker for differential diagnosis, prognostic judgement and effect of treatmeat.