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自乳化药物传递系统的研究概况 被引量：18

Recent Development of Self-emulsifying Drug Delivery System
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摘要 目的:总结自乳化药物传递系统的研究概况。方法:对近期自乳化药物传递系统的形成机制、处方组成、体外质量评价及其在药剂学方面的应用进行介绍。结果与结论:自乳化药物传递系统对亲脂性和水难溶性的药物是一个非常有前景的新型载体系统。 Objective:To review the advances of self-emulsifying drug delivery system.Methods:To synthesis systematically self-emulsifying drug delivery system,the mechanism of the formation,formulation design,method of evaluation in vitro and pharmaceutical application of self-emulsifying drug delivery system as a vehicle of the drug delivery system.Results and Conclusion:Self-emulsifying drug delivery system will have a very good prospect in pharmaceutics for these poorly soluble in water and lipophilic drugs.
作者 李莉 王中彦 莫凤奎
机构地区 沈阳药科大学药学院
出处 《中国药业》 CAS 2005年第2期25-27,共3页 China Pharmaceuticals
关键词 自乳化药物传递系统 自微乳化药物传递系统 乳化剂 self-emulsifying drug delivery system self-microemulsifying drug delivery system emulsion
分类号 R944.9 [医药卫生—药剂学]
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参考文献20

  • 1陈宗淇 戴闽光.胶体化学[M].北京:高等教育出版社,1985.270,271,342.
  • 2李国栋.中药挥发油自乳化释药系统[P].中国专利:02110783.1.2002-09-04.
  • 3何仲贵 崔升淼.葛根黄酮自微乳化软胶囊及其制备方法[P].中国:CN1457795A[P].2003—11—26.
  • 4何仲贵 唐景玲.银杏叶提取物自微乳化软胶囊及其制备方法[P].中国:CN1457796A[P].2003—11—26.
  • 5李国栋,范伟,居红卫,王捷频,张建明.自乳化释药系统的研究进展[J].国外医药（合成药．生化药．制剂分册）,2001,22(5):304-305. 被引量：29
  • 6张瑛,张钧寿,陈国广,张芳,王猛.盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨[J].中国药科大学学报,2002,33(3):208-210. 被引量：13
  • 7徐琛,张钧寿.自我乳化药物传递系统[J].药学进展,2001,25(1):21-24. 被引量：9
  • 8Gershanik T, Benita S. Positively charged self- emulsifying oil formulation for improving oral bioavailability of progesterone[J ]. Pharm Dev and Tech,1996,1(2):147 - 157.
  • 9Shah NH, Carvajal MT, Malick AW, et al. Self- emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs[ J ]. Int J Pharm, 1994,106(1): 15 -23.
  • 10Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption : physical and biopharmaceutical aspects [ J ]. Pharm Res,1995,12(11):1561 - 1572.

二级参考文献12

  • 1[1]Pouton, C. W. Formulation of self-emulsifying drug delivery systems[J]. Adv Drug Deliv Rev. 1997,25:47-58.
  • 2[2]Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceuticai aspects[J]. Pharm Res. 1995,12: 1561-1572.
  • 3[3]Holmberg I, Aksnes L, Berlin T, et al. Absorption of a pharmacological dose of vitamin D3 from two different lipid vehicles in man :comparison of peanut oil and a medium-chain Triglyceride[J]. Biopharm Drug Disposition, 1990, 11: 807-815.
  • 4[4]Shah NH, Carvajal MT, Patal CI, et al. Self-emulsifying drug delivery systems (SEDDS)with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs[J]. Int J Pharm, 1994,106: 15-23.
  • 5[5]Pouton CW. Self-emulsifying drug delivery systems :assessment of the efficiency of emulsification[J]. Int J Pharm,1985,27: 335-348.
  • 6[6]Pouton CW. Effects of inclusion of a model drug on the performance of Self-emulsifying formulations[J]. J Pharm Pharmac, 1984,36 : 51P.
  • 7[7]Charman SA, Charman WN, Rogge MC, et al. Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound[J].Pharm Res, 1992,9 (1):87-93.
  • 8[8]Lievens L, Hildegard SR. Pharmaceutical formulations of benzodiazepines [ P]. European Patent Application EP , 0 517412 A1,1992.
  • 9[9]Gershanik T, Benita S. Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone[J]. Pharm Dev and Tech, 1996,1(2):147-157.
  • 10[10]Gershanik T, Benzeno S,Benita S. Interaction of a selfemulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge[J]. Pharm Res, 1998,15(6): 863-869.

共引文献70

同被引文献178

引证文献18

二级引证文献93

中国药业
2005年 第2期

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