室安卡因、胺碘酮单用或合同治疗早搏的疗效对比

COMBINATION OF AMIODARONE WITH TOCAINIDE FOR THE TREATMENT OF PREMATURE CONTRACTION

总结用室安卡因、胺碘酮单用或合用治疗Lown分级Ⅱ级～Ⅴ级室早为主心律失常159例189例次,结果表明(1)合用组总有效率(95.9％),明显高于单用胺碘酮组(87.3％)和室安卡因组(77％),(P<0.005)。(2)二者合用早搏纠正时间(5.2天)分别较单用胺碘酮(8.3天)和室安卡因(5.8天)缩短。(3)合用与单用比较对传导及心率影响无差异。(4)合用后QTC延长发生率明显少于单用胺碘酮(P<0.05)。认为:对以Lown分级Ⅱ级以上室早为主心律失常可以选用室安卡因或胺碘酮,合用可增强疗效,减轻副作用。

The effects of amiodarone and/or tocainide in the treatment of the premature con traction of lown Ⅱ-Ⅴ were investigated in 159 cases with 189 total times treatment. the results showed as follows: (1) group A (tocainide group) : 50 patients recieving 61 times treatment entirely, the total effective rate was 76% ; group B (amiodarone group): 71 patients with 79 times treatment wholely, the total effective rate was 87. 3% ; group C (combination of tocainide with amiodarone) : included 38 patients, having 49times treatment totally, the total effective rate was 95. 9%. Compared with results among the three groups there was statistically significance (P<0. 05). (2) The average re treving time (5. 2days) of group C was shorter than those of group A (5. 8 days) and group B (8. 3 days). The retreving time of group B was remarkably longer than the other two groups. (3) The re sult of group C showed no significant difference for the conduction and cardiac rhythm. (4) The incidence of QT prolongation in group C was lower than that of group A and group B (P<0. 05). It is considered that the arrhythmia of entricular premature contraction above lown Ⅱ can apply tocainide and/or amiodarone. The effect of the treatment in the group C can be increased while the adverse of fects decreased.