苯那普利及吲哒帕胺对糖尿病伴高血压者血钾血糖影响

Effects of benazepril and indapamide alone or combined treatment on serum potassium and blood glucose in old patients with diabetes and hypertension

目的观察苯那普利、吲哒帕胺单药或联合治疗对老年2型糖尿病伴高血压病人血钾、血糖的影响.方法 90例原发性高血压病人,其中男49例,女41例,年龄60～78岁,平均(69±7)岁,分为3组,每组30例.苯那普利组服苯那普利10 mg每日1次,吲哒帕胺组服吲哒帕胺2.5 mg每日1次,联合治疗组两药同服,服法同上2组.3组疗程12周.检测各组治疗前后血钾,空腹血糖.结果苯那普利组血钾上升,空腹血糖降低,吲哒帕胺组血钾降低,空腹血糖升高(P均＜0.01),联合治疗组血钾、空腹血糖均无明显变化(P＞0.05).结论苯那普利与吲哒帕胺联用不仅联合降压,而且互相纠正单用引起的血钾、血糖波动的不良反应.

Objective To observe the effects of benazepril and indapamide alone or combined treatment on serum potassium and blood glucose in old patients with diabetes and hypertension. Methods Ninety patients, male 49, female 41, age(69±7), with essential hypertension were divided into three groups. The patients in benazepril group (n=30) were given benazepril 10 mg, qd for 12 weeks. The patients in indapamide group (n=30) were given indapamide 2.5 mg, qd for 12 weeks. The patients in combined group (n=30) were given both benazepril and indapamide that were used as described above. The levels of serum potassium and fasting blood glucose were examined before and after treatment in the three groups. Results The level of serum potassium elevated in benazepril group and reduced in indapamide group. The levels of fasting blood glucose reduced in benazepril group and elevated in indapamide group. All these were significantly different compared with that before treatments(P<0.01). In combined group, the levels of serum potassium and fasting blood glucose did not change remarkably after treatment(P>0.05). Conclusions Combination therapy with benazepril and indapamide not only has better antihypertensive efficacy, but also can offset the adverse fluctuant of serum potassium and fasting blood glucose caused by monotherapy of benazepril or indapamide.