感染性休克病死率和危险因素分析

ANALYSIS OF MORTALITY AND PREDICTIVE FACTORS OF SEPTIC SHOCK

目的回顾性分析感染性休克的病死率和相关危险因素。方法回顾性分析71例1994年1月～2004年10月源自中山大学附属第二医院的感染性休克患者资料,比较近10年死亡率的变化,对感染性休克的病死危险因素做单因素分析和多因素Logistic回归。结果1994年～2004年间,感染性休克患者的总死亡率是64.8%,近10年间病死率无明显变化(P=0.725);合并器官功能衰竭的数目越多,死亡率越高;性别(OR=0.206)、MODS数目(OR=11.387)、SIRS数目(OR=6.335)均是危险因素,其中MODS数目是强危险因素。结论近10年感染性休克的病死率无明显下降趋势,需注重防治MODS,及早采取各种保护器官功能的支持疗法。

OBJECTIVE: TO STUDY THE MORTALITY AND PREDICTIVE FACTORS OF SEPTIC SHOCK IN THE 2ND AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY. METHODS: 71 PATIENTS WITH SEPTIC SHOCK WERE STUDIED RETROSPECTIVELY. STEPWISE LOGISTIC REGRESSION ANALYSIS WAS PERFORMED TO ASSESS THE MORTALITY AND ITS PREDICTIVE FACTORS WITH SEPTIC SHOCK. RESULTS: THE OVERALL MORTALITY OF SEPTIC SHOCK WAS 64.8%,NO SIGNIFICANT CHANGED FROM 1994 TO 2004(P = 0.725). THE MORTALITY ASSOCIATED WITH SEX(OR=0.206), THE NUMBER OF ORGAN FAILURE (OR=11.387) AND THE NUMBER OF SIRS (OR=6.335). CONCLUSION: THE MORTALITY OF SEPTIC SHOCK SHOWED NO TREND OF DECLINE SINCE 1994. PREVENTION OF ORGAN DYSFUNCTION AND PROTECTION OF ORGANS ARE IMPORTANT.