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重组腺病毒IκBαM在裸鼠体内对人肝癌细胞HepG_2的凋亡作用 被引量：2

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作者 高小玲 贾丽萍 浦丹 闫歌 卢年芳 唐霓 黄爱龙
机构地区 重庆医科大学病毒性肝炎研究所
出处 《中华医学杂志》 CAS CSCD 北大核心 2004年第24期2120-2123,共4页 National Medical Journal of China
基金 国家"863"高技术研究发展计划基金资助项目(2001AA217121) 国家自然科学基金资助项目(30070297/C03020303)
关键词 核因子KB 凋亡作用 人肝癌细胞 IKBΑ HepG2 体内 重组腺病毒 蛋白质分子 外界刺激 磷酸化
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Menetski JP. The structure of the nuclear factor-KappaB protein-DNA complex varies with DNA-binding site sequence. J Biol Chem,2000, 275:7619-7625.
  • 2Waddick KG, Uckun FM, et al. Innovation treatment programs against cancer .Biochemical Pharmacol,1999,57:9-17.
  • 3Kucharczak J, Simmons MJ, Fan Y, et al. To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene,2003,22:8961-8982.
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  • 6Brown K, Gerstberger S ,Carlson L ,et al. Control of IkappaB-alpha proteolysis by site-specific,signal-induced phosphorylation.Science,1995,267:1485-1488.
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  • 8Xiang MQ, Huang AL, Tang N, et al. The expression of recombinant adenovirus IkappaBalphaM in human hepatocarcinoma HepG2 and its inhibitive effect on the activity of NF-kappaB. Natl Med J Chian,2003,83:1156-1160.
  • 9Zhou M, Gu L, Zhu N, et al. Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53. Oncogene, 2003,22:8137-8144.
  • 10Takaishi K, Ohtsuka T, Tsuneyoshi S, et al. Inhibition of the production of rat cytokine-induced neutrophil chemoattractant (CINC)-1, a member of the interleukin-8 family, by adenovirus-mediated overexpression of IkappaBalpha. J Biochem , 2000,127:511-516

二级参考文献43

共引文献34

同被引文献14

  • 1张克君,高焱明.核因子-κB p65在肝炎相关性肝细胞癌中的表达及意义[J].中国癌症杂志,2005,15(1):12-15. 被引量：5
  • 2张克君,李德春.重组腺病毒mIκBα基因的构建及体外抑制血管生成的作用[J].苏州大学学报（医学版）,2006,26(4):543-546. 被引量：3
  • 3张克君,李德春,高焱明,杨金镛,张炳远.NF-κB、MMP-9与肝细胞肝癌浸润转移的实验研究[J].中华肝胆外科杂志,2006,12(10):691-694. 被引量：15
  • 4Fujioka S,Sclabas GM,Schmidt C.Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis[J].Oncogene,2003,22(9):1365～1370.
  • 5Shuichi Fujioka,Guido M.Sclabas.Function of Nuclear Factor κ B in Pancreatic Cancer Metastasis[J].Clinical Cancer Research,2003,9(9):346～354.
  • 6Xiong HQ,Abbruzzese JL,Lin E.NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic Cancer cells[J].Int J Cancer,2004,108(2):181～188.
  • 7Huang S,Pettaway CA,Uehara H.Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogeneis,invasion,and metastasis[J].Oncogene,2001,20(31):4188～4197.
  • 8Futakuchi M,Ogawa K,Tamano S.Suppression of metastasis by nuclear factor-kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma[J].Cancer Sci,2004,95(1):18～24.
  • 9Huang S,Robinson JB,Deguzman A.Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin[J].Cancer Res,2000,60(19):5334～5339.
  • 10Ryan KM,Ernst MK,Rice NR.Role of NF-kappaB in p53mediated programmed cell death[J].Nature,2000,404(6780):892～897.

引证文献2

二级引证文献7

中华医学杂志
2004年 第24期

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