期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

前药转换酶/前药体系的研究进展 被引量：1

Progress in study of prodrug-activating enzyme/prodrug system
下载PDF
导出
摘要 前药转换酶 /前药体系是自杀基因疗法的核心 ,关系到自杀基因疗法的成败 ,近年来得到深入研究。就前药转换酶 /前药体系的种类、作用机制和体外。 The prodrug-activating enzyme/prodrug system is the most important component of suicide gene therapy,in which further investigations have been carried out.The varieties,mechanism and in vitro/ in vivo effect of popular enzyme/prodrug systems have been reviewed herein.
作者 陈建发 黄宗海
机构地区 第一军医大学珠江医院普通外科
出处 《肿瘤防治杂志》 2004年第4期417-421,共5页 China Journal of Cancer Prevention and Treatment
关键词 肿瘤/治疗 基因疗法 药物前体 转导 遗传 转染 综述文献 neoplasms/therapy gene therapy prodrug transduction heredity transfection review literature
分类号 R456 [医药卫生—治疗学]
  • 相关文献

参考文献29

  • 1Springer C J,Niculescu-Duvaz I. Prodrug-activating systems in suicide gene therapy[J].J Clin Invest,2000,105(9):1161-1167.
  • 2Culver K W,Ram Z,Wallbridge S,et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors[J]. Science,1992,256(5063):1550-1552.
  • 3Nicholas T W, Read S B, Burrows F J,et al. Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effects[J]. Histol Histopathol,2003,18(2):495-507.
  • 4Asklund T, Appelskog I B, Ammerpohl O, et al. Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene[J]. Exp Cell Res,2003,284(2):185-195.
  • 5Touraine R L,Ishii-Morita H,Ramsey W J,et al. The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication[J].Gene Ther,1998,5(12):1705-1711.
  • 6Freeman S M,Ramesh R,Marrogi A J. Immune system in suicide-gene therapy[J].Lancet,1997,349(9044):2-3.
  • 7Agard C, Ligeza C, Dupas B,et al. Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis[J]. Cancer Gene Ther,2001,8(2):128-136.
  • 8Xu G,McLeod H L. Strategies for enzyme/prodrug cancer therapy[J].Clin Cancer Res,2001,7(11):3314-3324.
  • 9Denny W A. Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)[J]. J Biomed Biotechnol,2003,2003(1):48-70.
  • 10Greco O, Dachs G U. Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives [J]. J Cell Physiol,2001,187(1): 22-36.

同被引文献11

  • 1陈建发,黄宗海,黄元媛,宋慧娟,车小燕.应用AdEasier-1系统高效制备含VEGFP驱动TK自杀基因的重组腺病毒[J].癌症,2004,23(9):1093-1097. 被引量：5
  • 2Xu G, McLeod H L. Strategies for enzyme/prodrug cancer therapy[J].Clin Cancer Res,2001,7(11):3314-3324.
  • 3Cascinu S, Aschele C, Barni S, et al. Thymidylate synthase protein expression in advanced colon cancer:correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil[J]. Clin Cancer Res, 1999,5(8):1996-1999.
  • 4Freytag S O, Paielli D, Wing M, et al. Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model[J]. Int J Radiat Oncol Biol Phys, 2002, 54(3):873-885.
  • 5Lee Y J, Lee H, Borrelli M J. Gene transfer into human prostate adenocarcinoma cells with an adenoviral vector: Hyperthermia enhances a double suicide gene expression, cytotoxicity and radiotoxicity[J]. Cancer Gene Ther, 2002,9(3):267-274.
  • 6Lee Y J, Galoforo S S, Battle P, et al. Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy[J]. Cancer Gene Ther, 2001,8(6):397-404.
  • 7Hirano T, Kaneko S, Kaneda Y, et al. HVJ-liposome-mediated transfection of HSVtk gene driven by ATP promoter inhibits hepatic tumor growth of hepatocellular carcinoma in SCID mice[J].Gene Ther,2001,8(1):80-83.
  • 8Pandha H S, Martin L A,Rigg A, et al.Genetic prodrug activation therapy for breast cancer:a phaseⅠclinical trial of erbB-2-directed suicide gene expression[J]. J Clin Oncol, 1999,17(7):2180-2189.
  • 9Kaliberov S A, Buchsbaum D J, Gillespie G Y, et al. Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells[J]. Mol Ther,2002,6(2):190-198.
  • 10黄宗海,陈治,钱伟峰,王晓莉,张莉,潘玉先,曹长安.血管内皮细胞生长因子及其受体在大肠癌组织中的表达[J].第一军医大学学报,2001,21(3):206-208. 被引量：11

引证文献1

肿瘤防治杂志
2004年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部