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乳腺癌反义治疗的研究进展 被引量：2

Reserch advances in breast cancer for antisense therapy
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摘要 反义技术是基因治疗的一个策略。反义寡核苷酸对癌基因的特异性封闭作用可抑制基因的表达 ,阻止癌症的发展与恶化。综述了乳腺癌c erbB Antisense technology is a strategy of gene therapy.The specific blocking action of antisense oligonucleotide can suppress gene expression and prevent the progression and deterioration of cancer.The article summarizes the antisense c-erbB-2 gene therapy strategy for mammary cancer and the clinical significance of antisense drug.
作者 谢娟 李少林
机构地区 贵州省人民医院药剂科
出处 《肿瘤防治杂志》 2004年第5期546-549,共4页 China Journal of Cancer Prevention and Treatment
关键词 乳腺肿瘤/治疗 寡核苷酸类 反义 基因 c-erbB-2 综述文献 breast neoplasms/therapy oligonucleotides,antisense genes,c-erbB-2 reviews literature
分类号 R737.9 [医药卫生—肿瘤]
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参考文献26

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  • 2Yamauchi H,Stearns V,Hayes D F. When is a tumor Marker ready for prime time?A case study of c-erbB-2 as a predictive factor in breast cancer[J].J Clin Oncol,2001,19(8):2334-2356.
  • 3Harari D,Yarden Y. Molecular mechanisms underlying erbB-2/HER-2 action in breast cancer[J].Oncogene,2000,19(53):6102-6114.
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  • 9Yip Y L,Ward R L. Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines[J].Cancer Immunol Immunother,2002,50(11):569-587.
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肿瘤防治杂志
2004年 第5期

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