颅内肿瘤继发癫痫发作62例临床与脑电图分析

Analysis of clinical signs and EEG in 62 cases of epilepsy secondary from brain neoplasms

为探讨颅内肿瘤与癫痫的关系和发生机制 ,以提高颅内肿瘤早期诊断率。回顾分析经手术切除病理证实的颅内肿瘤 2 45例 ,其中继发性癫痫发作 62例临床与脑电图进行分析。结果颅内肿瘤继发癫痫发作 2 0岁以上发病率为67 7% ;以脑胶质瘤癫痫发病率最高 5 4 8% ,其次是脑膜瘤 2 5 8% ,转移瘤 19 4% ;部位以额叶癫痫发病率最高 3 8 7% ,其次为顶叶 2 0 9%等 ;脑电图异常率 87 1%。初步研究结果提示 ,成年人癫痫多为继发性癫痫 ,在排除外伤、脑血管病后 ,应高度警惕患颅内肿瘤的可能 ,脑电图对颅内肿瘤早期诊断和判断有无肿瘤复发都有一定参考价值。

The objective of this study is to explore the relationship between brain neoplasms and epilepsy as well as its mechanism. Clinical signs and electroencephalogram(EEG) in 245 patients with neoplasms were analyzed retrospectively. Of them,62 cases were secondary from epilepsy. Tissue specimens were obtained by biopsy, and confirmed by histological evaluation.The incidence of epilepsy secondary from brain neoplasms in adults was 67.7%.The incidence of epilepsy in patients with glima was the highest (54.8%), and that of meningioma the second (25.8%), that of metastatic encephaloma the third (19.4%).The epileptic focus location: frontal lobe was the highest (38.7%), parietal lobe was the second (20.9%).The abnomality rate of EEG was 87.1%.In conclusion,most of epilepsy in adults is secondary from other diseases. High attention should be paid on brain neoplasms when injury and ceredrovascular diseases were excluded. The EEG might have important clinical application value on early diagnosis of brain tumors as well as its recurrence. [