阳离子聚合物载体在体内基因治疗中的应用
被引量:2
Cationic Polymer Gene Delivery Systems for in vivo Applications
摘要
基因治疗是一种对各种与基因相关、威胁到人类生命的疾病有重要潜在治疗作用的一种新的治疗方法[1].基因治疗在四十多年的发展道路上取得了很多惊人的成就,也遇到了很多困难.目前基因治疗要真正进入临床应用,还有一些根本问题没有解决,其中最重要的是安全、高效及可控的基因载体的构建[2].
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
2004年第4期235-238,共4页
Chinese Journal of Cancer Biotherapy
基金
国家高技术研究发展计划(863计划)项目(E220-01-01)
参考文献23
-
1Reschel T, Konak C, Oupicky D, et al. Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations. J Control Release,2002, 81(1-2): 201-217.
-
2Ward CM, Pechar M, Oupicky D, et al. Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folatemediated targeting in vitro and prolonged plasma circulation in vivo. J Gene Med, 2002, 4(5): 536-547.
-
3Mannisto M, Vanderkerken S, Toncheva V, et al. Structure-activity relationships of poly (L-lysines): Effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery[J]. J Control Release, 2002, 83(1): 169-182.
-
4Pouton CW, Lucas BJ, Thomas, et al. Polycation-DNA complexes for gene delivery: A comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids [ J ]. J Control Release, 1998, 53 (1-3): 289-299.
-
5Sadler K, Tam JP. Peptide dendrimers: Applications and synthesis[J]. J Biotechnol, 2002, 90(3-4): 195-229.
-
6Kinnon C, Levinsky RJ. Somatic gene therapy for genetic disease [J]. Arch DisChild, 1990, 65(1): 72-73.
-
7Kircheis R, Blessing T, Brunner S, et al. Tumor targeting with surface-shielded ligand-polycation DNA complexes [ J ]. J Control Release, 2001,72(1-3): 165-170.
-
8Boussif O, Lezoualch F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo:Polyethylenimine[ J]. Proc Natl Acad Sci U S A, 1995, 92(16):7297-7301.
-
9Pouton CW, Seymour LW, Key issues in non-viral gene delivery [J]. Adv Drug Deliv Rev, 2001,46(1-3): 187-203.
-
10Wolfert MA, Seymour L.W. Atomic force microscopic analysis of the influence of the molecular weight of poly(L) lysine on the size of polyelectrolyte complexes formed with DNA [ J ]. Gene Ther,1996, 3(3): 269-273.
同被引文献25
-
1Kursa M,Walker G F,Roessler V,et al.Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer.Bioconjug Chem,2003,14 (1):222-231.
-
2Kircheis R,Blessing T,Brunner S,et al.Tumor targeting with surface-shielded ligand--polycation DNA complexes.J Control Release,2001,72 (1-3):165-170.
-
3Lee H,Jeong J H,Park T G.PEG grafted polylysine with fusogenic peptide for gene delivery:high transfection efficiency with low cytotoxicity.J Control Release,2002,79 (1 -3):283-291.
-
4Lee H,Kim T H,Park T G.A receptor-mediated gene delivery system using streptavidin and biotin-derivatized,pegylated epidermal growth factor.J Control Release,2002,83 (1):109-119.
-
5Lee H,Jeong J H,Park T G.A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptide.J Control Release,2001,76 (1-2):183-192.
-
6Guo Y,Sun Y,Li G,et al.The molecular structure ofpoly(ethylene glycol)-modified nonviral gene delivery polyplexes.Molecular Pharmaceutics,2004,1 (6):477-482.
-
7Nah J W,Yu L,Han S O,et al.Artery wall binding peptide-poly(ethylene glycol)-grafted-poly (L-lysine)-based gene delivery to artery wall cells.J Control Release,2002,78 (1-3):273-284.
-
8Woodle M C,Scaria P,Ganesh S,et al.Sterically stabilized polyplex:ligand-mediated activity.J Control Release,2001,74 (1 -3):309-311.
-
9Blessing T,Kursa M,Holzhauser R,et al.Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery.Bioconjug Chem,2001,12 (4):529-537.
-
10Ogris M,Steinlein P,Carotta S,et al.DNA/polyethylenimine transfection particles:influence of ligands,polymer size,and PEGylation on internalization and gene expression.AAPS PharmSci,2001,3 (3):E21.
-
1顾方舟.中国生物医学工程的发展道路[J].中国生物医学工程学报,1991,10(1):1-5. 被引量:1
-
2汤祥华,全仁夫.医用纳米生物材料基因相容性的研究进展[J].中医正骨,2008,20(3):63-65.
-
3顾方舟.中国生物医学工程发展道路的探讨[J].现代化,1991,13(8):20-23.
-
4黄建,李跃辉,郭锋杰,童永清,王甲甲,胡锦跃,李官成.人源抗肝癌单链抗体SA3与增强型绿色荧光蛋白的融合表达及其体内靶向性研究(英文)[J].中南大学学报(医学版),2011,36(10):979-986. 被引量:1
-
5代宏剑,张再兴.基因分型在疟原虫虫株鉴别中的应用研究现状[J].中国人兽共患病学报,2009,25(7):694-696.
-
6华赟鹏,赖佳明,李绍强,汪勇,王瑛,李宝金,朱宝益.甲胎蛋白启动子驱动的yCDglyTK双自杀基因治疗裸鼠肝癌的机制研究[J].中华普通外科学文献(电子版),2009,3(2):12-14.
-
7苗莉.“我”与“我的”体悟[J].人人健康,2009(18):66-66.
-
8东主措.论现代兽医行业的科学化发展道路[J].大观周刊,2013(7):286-287.
-
9郭洪刚,马信龙.组织工程学策略再生椎间盘的研究进展[J].中国矫形外科杂志,2009,17(1):37-39. 被引量:4
-
10佘靖.走突出自身特色的发展道路[J].中国卫生,2006(2):12-13.