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肾癌G250MN/CAIX抗原的研究进展 被引量：3

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摘要 肾癌G2 5 0抗原是其特异性抗原 ,相应抗体及瘤苗在动物与临床试验中取得阶段性成果 ,展示了对肾癌的诊断、治疗和监测的良好应用前景。本文对肾癌G2 5 0抗原的蛋白组成、基因结构、理化性质以及在肾癌的诊断。
作者 张亚东 李晓飞
机构地区 广州中山大学附属第一医院泌尿外科
出处 《国外医学（泌尿系统分册）》 2005年第1期12-16,共5页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
关键词 抗原 肿瘤 抗体 单克隆
分类号 R737.11 [医药卫生—肿瘤]
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参考文献18

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  • 2Opavsky R,Pastorekova S,Zeinik V,et al.Gene,a novel member of the carbinic angydase familu:structure and exon to protein domain relationships.Genomics,1996,33:480-487.
  • 3Grabmaier K,Vissers JL,De Weijert MC,et al.Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250.Int J Cancer,2000,85(6):865-70.
  • 4Cho M,Uemura H,Kim SC,et al.Hypomethylation of the MN/CA9 promoter proximal region(SP) and upregulated MN/CA9 expression in human renal cell carcinoma.Br J Cancer,2001,85:563-567.
  • 5Vissers JL,De Vries IJ,Engelen LP,et al.Renal cell carcinoma-associated antigen G250 encodes a naturally processed epitope presented by human leukocyte antigen-DR molecules to CD4(+) T lymphocytes.Int J Cancer,2002,100(4):441-4.
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同被引文献20

  • 1李科,苏泽轩,李君武.肾癌生物治疗的研究进展[J].中国医学工程,2008,16(4):279-282. 被引量：1
  • 2任淑萍,包木胜,高新,于永利,王丽颖.HSP65-MUC1/HSP65抗体免疫复合物对人树突状细胞的活化作用[J].吉林大学学报（医学版）,2005,31(2):182-185. 被引量：6
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  • 6Grabmaier K,Vissers JL,De Weijert MC,et al.Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250.Int J Cancer,2000,85:865 -870.
  • 7Krutzik SR,Tan B,Li H,et al.TLR activation triggers the rapiddifferentiation of monocytes into macrophages and dendritic cells[J].Nat Med,2005,11(6):653-660.
  • 8Reinhard G,Marten A,Kiske SM,et al.Generation of dendriticcell-based vaccines for cancer therapy[J].Br J Cancer,2002,86(10):1529-1533.
  • 9Akiyama K,Ebihara S,Yada A,et al.Targeting apoptotic tumorcells to FcγR provides efficient and versatile vaccination againsttumors by dendritic cells[J].J Immunol,2003,170(4):1641-1648.
  • 10Dubois B,Lamy PJ,Chemin K,et al.Measles virus exploits den-dritic cells to suppress CD4+T-cell proliferation via expression ofsurface viral lycoproteins independently of T-cell trans-infection[J].Cell Immunol,2001,214(2):173-183.

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国外医学（泌尿系统分册）
2005年 第1期

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