维持胚胎干细胞自我更新分子机制的研究进展

Progress in The Study of Molecular Mechanism Maintaining Embryonic Stem Cells Self-renewal *

胚胎干细胞通过特殊内源性分子的表达 ,以及微环境中多种细胞因子和胞外基质的刺激 ,构成信号网络 ,共同调控自我更新 .近年来 ,通过对Oct3/4、Nanog等胚胎干细胞特殊分子标记 ,以及LIF STAT3,Wnt β 连环素 ,BMP Id等信号通路的研究 ,探讨了胚胎干细胞自我更新信号网络的分子机制 .维持自我更新的关键在于胚胎干细胞生长微环境中的各种细胞因子和胞外基质的含量 ,以及细胞内源性特异分子表达量之间的平衡 .

Some intrinsic ESC-specific markers, cytokines and extracelluar matrix in the microenvironment compose of a complex network to co-regulate ESC self-renewal. The molecular mechanism of signal network maintaining ESC self-renewal was investigated by studying the ESC-specific markers, such as Oct-4 and Nonog recently. Moreover, ESC signal pathways, just like LIF-STAT3, Wnt-beta-catenin and BMP-Id, were further deeply studied. In conclusion, the most important key to maintain ESC self-renewal is the balance among the content of various cytokines, extracelluar matrix, and expressing quantity of intrinsic ESC-specific markers by different signal stimulators.