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帕金森病外周血T细胞亚群的研究 被引量：8

Study on T Lymphocyte Subsets in Parkinson's Disease
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摘要 目的 :探讨PD患者PBL免疫功能的变化。方法 :通过直接免疫荧光标记法 ,应用流式细胞仪 ,测定 3 5例PD患者与 18名健康对照者CD3 + 、CD4+ 、CD8+ 淋巴细胞亚群百分比及淋巴细胞总百分比 ,计算CD4+ /CD8+ 的比值。结果 :PD患者CD4+ T细胞百发比和淋巴细胞总百分比降低 ,CD8+ T细胞的百分比不变 ,CD4+ /CD8+ 的比值较正常人显著降低 ,男性患者上述指标的下降更明显。多巴制剂的服用对淋巴细胞亚群的变化无影响。结论 :PD患者存在细胞免疫功能的异常。 Aim:To study the immune function of Parkinson's disease.Methods:T lymphocyte subsets (including CD3+,CD4+,CD8+ percent and ratio of CD4+,CD8+)of 35 PD patients and 18 healthy donors was measured by fluorescence-activated cell sorter (FACS).PD patients were including of dopa-treated and dolpa-naive group.Results:CD4+ T cell percent and ratio of CD4+/CD8+ were notably depress ed in PD than in healthy subjects.Differences in male PD is more significant.Total lymphocyte percent is also significantly lower.T cell (CD3+)and CD8+ T cell percent is normal.Levodopa has not shown effect on T lymphocyte subsets among PD patients.Conclusion:Cytoimmune mechanism may play an important role in pathogenesis of PD.
作者 陈女燕 蒋雨平 朱萍
机构地区 复旦大学附属华山医院神经内科血液科 复旦大学上海医学院神经病学系
出处 《中国临床神经科学》 2004年第4期377-380,共4页 Chinese Journal of Clinical Neurosciences
关键词 患者 PD 亚群 CD4^+/CD8^+ 外周血T细胞 帕金森病 比值 多巴 变化 流式细胞仪 Parkinson's disease peripheral blood lymphocyte T-lymphocyte subset fluorescence-activated cell sorter
分类号 R742.5 [医药卫生—神经病学与精神病学] R392 [医药卫生—免疫学]
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参考文献10

  • 1Bas J,Calopa M,Mestre M,et al.Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism[J].J Neurommunol,2001,113:146-152
  • 2Hisanaga K,Asagi M,Itoyama Y,et al.Increase in peripheral CD4 bright+ CD8 dull+ Tcells in parkinson disease[J].Arch Neurol,2001,58:1580-1583
  • 3雷革胜,苗建亭,李柱一.帕金森病患者外周血T淋巴细胞亚群及红细胞免疫研究[J].中国神经免疫学和神经病学杂志,2001,8(2):95-97. 被引量：9
  • 4谭峰,顾卫,黄涛,张睿铸.帕金森病患者NK细胞亚群及T淋巴细胞亚群变化的临床意义[J].中国免疫学杂志,2003,19(2):138-140. 被引量：10
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二级参考文献10

  • 1[8]Fiszer U,Piotrowska K,Korlak J et al. The immunological status in Parkinson disease[J].J Med,1997;4:199.
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  • 9黄鉴政.第三届全国锥体外系疾病学术会议纪要[J].中华神经科杂志,1997,30(4):199-200. 被引量：3
  • 10罗毅.帕金森病的诊断标准及其评分[J].中国实用内科杂志,1999,19(6):325-328. 被引量：23

共引文献11

同被引文献92

引证文献8

二级引证文献15

中国临床神经科学
2004年 第4期

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