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α-synuclein与帕金森病 被引量:4

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摘要 α synuclein是路易小体的主要成分 ,可能通过破坏多巴胺存储与释放、增加氧化应激等机制 ,在多巴胺神经元变性中起作用。
出处 《中国临床神经科学》 2004年第4期434-437,共4页 Chinese Journal of Clinical Neurosciences
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  • 1Ploymeropoulos MH,Lavedan C,Leroy E,et al.Mutation in the alpha-synuclein gene identified in families with Parkinson's disease[J].Science,1997,276:2405-2407
  • 2Trojanowski JQ,Lee VM."Fretal attractions"of proterins.A comprehensive hypothetical mechanism underlying Alzheimers's disease and other neurodegenerative disorders[J].Ann NY Acad Sci,2000,924:62-67
  • 3Vladimir N,Lie J,Anthony L,et al.Metal-triggered structural transformation aggregation and fibrillation of human alpha-synuclein[J].J Biol Chem,2001,276:44284-44294
  • 4Uversky VN,Li J,Fink AL.Pesticides directly accelerate the tate of alpha-synuclein fibril formation:a possible factor in Parkinson's disease[J].FEBS Lett,2001,500:105-108
  • 5Bennett MC,Bishop JF,Leng Y,et al.Degradation of α-synuclein by proteasome.J Biol Chem[J].1999,274:33855-33858
  • 6McNaught KS,Jenner P.Proteasomal function is impaired in substantia nigra in Parkinson′s disease[J].Neurosici Lett,2001,297:191-194
  • 7McNaught KS,Mytilineou C,Baptiste RJ,et al.Impairment of the ubiquitin-proteasome causes dopaminergic cell death and inclusion body formation in ventral mesencephlic cultures[J].J Neuro Chem,2002,81:301-306
  • 8Bence NF,Sampat RM,Kopito RR,et al.Impairment of the ubiquitin-proteasome system by protein aggregation[J].Science ,2001,292;1552-1555
  • 9Uversky VN,Li J,Anthony L,et al.Biophysical properties of the synucleins and their propensities to fibrillate:inhibition of alpha-synuclein assembly by β- and γ-synuceins[J].J Biol Chem,2002,277:11970-11978
  • 10Feany MB,Bender WW.A drosophila model of Parkinson's disease[J].Nature,2000,404;394-398

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