维生素E对移植器官慢性排斥反应的影响

Effect of vitamin E on the chronic graft rejection

目前 ,移植领域的一个重要方向就是诱导多机制起作用的免疫耐受 ,防治人体对同种异体器官的慢性排斥反应。作者列举了该方向在免疫因素和非免疫因素方面一些新的发现 ,总结了大剂量维生素E(VE)对免疫系统的调节作用 ,是通过Th/Ts比值的改变和不提高特异性抗体水平来实现的。同时 ,VE强大的抗氧化作用有助于减轻移植组织的氧化压力和血管损伤 ,展望了VE用于防治移植器官慢性排斥反应的意义以及存在问题。

At present, the immunological tolerance in transplantation induced by multi-mechanisms, to inhibit the chronic graft rejection, represents an important trend in the field of transplantation. This review summarizes the new researches about immune and non-immune factors in this field. At the same time, this review also discusses that the high-dose vitamin E, through changing the ratio of Th/Ts in vivo and not improving the level of specific-antibody, regulates the immune system. In addition, the potent antioxidation of vitamin E has advantage to release the oxidate press of tissue and the damage of blood vessels. In the end, the reporter prospects the signification of vitamin E to inhibit the chronic graft rejection and points out the potential questions.