慢性牙周炎病变部位白细胞介素-8表达的初步研究

Preliminary Study on IL-8 Expression in Inflammatory Sites of Chronic Periodontitis Patients

目的 探讨牙龈组织中白细胞介素 8(IL 8)与慢性牙周炎的关系。方法 采用免疫组化法检测 32例牙龈组织样本 (16例健康者 ,16例慢性牙周炎患者 ) ,分析IL 8的检出率及IL 8分泌细胞在牙龈组织中的分布。结果 慢性牙周炎患者中的IL 8的检出率均高于健康者 ,IL 8阳性细胞分布于牙龈的上皮和结缔组织中。结论 研究结果提示IL 8参与了牙周炎的病理过程。

Objective To explore the relationship between interleukin-8 (IL-8) and chronic periodontitis (CP). Methods Immuno-histo-chemistry technique was used to measure the levels of IL-8 and to identify the IL-8 positive cells in gingival tissue in 32 samples (16 healthy volunteers, 16 CP patients). Results The levels of IL-8 in CP group were significantly higher than that in healthy group and the IL-8 positive cells located in gingival epithelium and gingival connective tissue. Conclusion IL-8 took part in the pathological process of periodontitis.